STUDY PROTOCOL FOR A RANDOMISED CONTROLLED TRIAL TO EVALUATE THE USE OF MELANOMA SURVEILLANCE PHOTOGRAPHY TO THE IMPROVE EARLY DETECTION OF MELANOMA IN ULTRA-HIGH AND HIGH-RISK PATIENTS (THE IMAGE TRIAL)

Abstract Introduction Melanoma surveillance photography (MSP) is a comprehensive surveillance method that comprises two- or three-dimensional total body photography with tagged digital dermoscopy, performed at prescribed intervals.It has the potential to reduce unnecessary biopsies and enhance early detection of melanoma, but it is not yet standard

Ethical regulations and limited paediatric participants are key challenges that contribute to a median delay of 6 years in paediatric mAb approval.To overcome these barriers, modelling and simulation methodologies have been adopted to design optimized paediatric clinical studies and reduce patient burden.The classical modelling approach in paediatr

A roof?rib pillar support system is often formed in the metal mines that applied to the backfill mining method.In order to ensure the safe mining, it is of great significance to explore the failure mechanism of the roof?rib pillar support system under backfill mining.On the basis of considering the side pressure effect of the backfill on the rib pi

Abstract The electrochemical and photochemical properties of graphene derivatives could be significantly improved by modifications in the chemical structure.Herein, reduced graphene oxide (RGO) was functionalized with l-arginine (l-Arg) by an amidation reaction between the support and amino acid.Deposition Biscuits of a powerful ligand, l-Arg, on t

Rheumatoid arthritis (RA) and Type 2 diabetes (T2D) are both systemic diseases linked with altered immune response, moderate mortality when present together.The treatment for both RA and T2D are not satisfied, partly because of the linkage between them has not yet been appreciated.A comprehensive study for the potential associations between the two